Matrix Metalloproteinase 14

A transmembrane domain-containing matrix metalloproteinase. It is synthesized as an inactive zymogen that is activated by the action of PROPROTEIN CONVERTASES such as FURIN. Matrix metalloproteinase 14 plays a direct role in the cleavage of proteins in the pericellular environment. In addition, it can function indirectly by enzymatically activating the proprotein form of MATRIX METALLOPROTEINASE 15.

Also Known As:

MT1-MMP; Membrane-Type Matrix Metalloproteinase 1; MMP-14 Metalloproteinase; MMP-X1 Protein; MMP14 Metalloproteinase; MT-MMP-1; MT1-Matrix Metalloproteinase; Membrane-Type 1 Matrix Metalloproteinase; MMP 14 Metalloproteinase; MMP X1 Protein; MT1 Matrix Metalloproteinase; Membrane Type 1 Matrix Metalloproteinase; Membrane Type Matrix Metalloproteinase 1; Metalloproteinase 14, Matrix; Metalloproteinase, MMP-14; Metalloproteinase, MMP14; Metalloproteinase, MT1-Matrix

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Hydrolases: 2206
    - Peptide Hydrolases: 24289
      - Metalloproteases: 8398
        Metalloendopeptidases: 70
        Matrix Metalloproteinases: 22474
        Membrane-Associated Matrix Metalloproteinases: 71
        Matrix Metalloproteinase 14: 1085
      - Endopeptidases: 643
        Metalloendopeptidases: 70
        Matrix Metalloproteinases: 22474
        Membrane-Associated Matrix Metalloproteinases: 71
        Matrix Metalloproteinase 14: 1085

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Disease

Drug/Important Bio-Agent (IBA)